10 min read AlphaFold Protein structures are defined, experimentally, by X-ray crystallography, nuclear magnetic resonance and electron cryomicroscopy (cryo-EM). However, these techniques are complex, time consuming, expensive and the protein is often not in its native form (Bertoline et al., 2023). Therefore, from its introduction in 2018, DeepMind’s AlphaFold program has […]
20 min read. The adeno-associated virus (AAV) was first discovered in 1965 as a contaminant of adenovirus preparations, subsequently AAV was found in human tissues. Pure scientific curiosity in understanding basic AAV biology is what led to realising the tremendous potential of AAV as a vector in human gene therapies. AAV vectors are now the […]
15 min read. Chemotherapeutic agents used to treat cancer require accurate dosing to prevent serious adverse toxicities. For those drugs excreted through the kidney, a precise understanding of kidney function (as measured by glomerular filtration rate, GFR) is needed to ensure drug toxicity is avoided. Carboplatin is unique among chemotherapeutic agents in that its dosing […]
Extracellular vesicles (EVs) play a crucial role in mediating cell-to-cell communication. They are involved in several physiological and pathological processes within the body, including cancer development, and potential use as non-invasive cancer biomarkers. However, the extensive heterogeneity in size, composition, and origin of EVs makes their accurate and reliable characterization and detection crucial to meet […]
Publishing a research paper is a significant milestone in any academic or professional career. It’s an achievement that requires hard work and dedication. We wanted to take a moment to acknowledge our lab manager’s Dr. Carolyn Hyde, amazing work on this recent research paper, “Domestic Animal Endocrinology”. Let’s take a summarised dive into this blog […]
According to national statistics published by the government, between April 2020 and March 2021, 275,896 adults came into contact with drug and alcohol services (1). Testing for drugs of abuse can be used to a) discover drug abuse; b) monitor someone who has a substance abuse problem; c) detect drug intoxication and d) determine the […]
We recently came across this very interesting article about calibration curve standards, published at Restek by Dr. Landon Wiest. At the Bio-Analysis Centre, preparing calibration curves are part of our work. Thus, we would like to share this article which reveals important tips on how to do it and avoid errors. The first step to […]
Alongside analytical services we also provide training courses on Shimadzu Nexera XP HPLC and Shimadzu LCMS-8040, these include: 3 day HPLC analysis 5 day LCMS analysis 1 day HPLC refresher course 1 day general laboratory skills To get an understanding of the benefits of our courses, we asked those who had been previously trained questions […]
Here at the Bio Analysis Centre we have the capability to run samples through our UHPLC (Ultra High Performance Liquid Chromatograph) or LCMS (Liquid Chromatograph Mass Spectrometer). Shimadzu (1), the manufacture of the machinery, ran a Multiple Residue Analysis of 210 Pesticides in Food Samples by Triple Quadrupole UHPLC – MS/MS. Pesticide residue on […]
We were delighted to be asked to join the panel last night at the One Nucleus event hosted by LBIC at the RVC. The topic, ‘Staffing the 21st Century Life Sciences R&D Industry.’ As an employer of several graduates, undergraduates and summer placements in our 5 years of business, we were interested to be […]